Ghana is a very safe Country. The hospitality of Ghanaians 
will amaze you. 

However:  
            

Crime
As in every human society, Accra has its share of crime, though it is generally regarded as being relatively safe and peaceful. Pick-pocketing, purse snatching, and various types of scams are the most common forms of crime confronting visitors. Travelers have reported instances of these types of theft in crowded market areas, beaches and parks, and at tourist attractions. Violent crime is on the rise, particularly in and around Accra, Tema, and Kumasi. Travelers who limit their display of jewels and handle their cash discreetly reduce their vulnerability to crime. Armed robberies have occurred in and around Accra and Tema. Travelers should remain alert to their surroundings, especially when leaving banks. Visitors should exercise caution in Osu, Jamestown and Nima, particularly after dark. Theft of luggage and travel documents occurs at Kotoka airport in Accra. Visitors should be wary of all unsolicited help at the airport unless the individual carries a current photo ID. A growing number of travelers have been victims of credit card fraud after having used their credit cards in Ghana.

Clothing
Wear light summer clothing preferably in cotton. Avoid synthetic fabric in all seasons.Don't wear any military clothing or sportswear with a camouflage design - it's illegal. Don't wear shorts except for sporting events.

Health
Boil your non-tap drinking water.
Avoid street food and water. Be very careful of what enters your body.
Be weary of prostitutes, and remember that AIDS is real, so do protect yourself if you must entertain them. Remember 'prevention is better then cure'. Always move in a group.

Money Exchange
Change your foreign money at the forex bureau. No matter the amount, count before leaving premises. Good bureaus have counting machines. In a big town or city avoid the roadside money changers. They'll cheat you. You'll realize this only when you get home. Don't exchange more money than you need at a time (not more than 3 days time). Avoid Saturday night exchange of money, the rates are terrible To be a good sprinter like Ghana inflation, make sure that whatever you want to buy is at hand before you exchange your foreign currency.

Transportation
Always travel on STC buses whenever possible. They are more comfortable and a lot safer.

Shopping
Always shop with a "proper" Ghanaian with you. Alternatively, let somebody you trust shop for you otherwise you'll pay double the price. If you have to do the shopping yourself first check the prices in the shops. If you have to shop outside (bargain) first check the prices at the shops. Then you'll never pay more than it costs in the shops.Don't expect much of anything to be open on Sunday.

Mind Your Ghanaian Manners
Dashes (tips) are a way of life in Ghana. Rather than calling it a bribe, a dash is a tip that may be requested by anyone from train conductors who seat you to youngsters who may run errands for you. Seen as gifts, dashes will ease your way through Ghana immensely, and are usually about 5,000 cedis (67 cents).

When taking photos, always ask the person beforehand, and you may be asked to give a dash as well.

Do observe the "left-hand taboo" - it's rude to eat, give or receive anything with the left hand, which is reserved for personal hygiene. And - while we are on the subject - be sure to take your own toilet paper

Always shake hands and pick up food with your right hand, since the left is used to perform other personal functions.

When meeting a chief or village elder, always lower yourself or bow with your knees to show respect. Learning a few words of Twi (akwaaba means welcome) will make you a big hit among Ghanaians. Be sure to always smile and wave to strangers-everyone loves it and invariably waves back.

Others
Do not swim in the LAKES or RIVERS

Do greet people properly. In Ghana, "Morning" is the standard greeting in the early part of the day. The local reply is "Morning, morning," which will be answered by "Fine morning."

Don't try to bribe anyone with cigarettes. Smoking is considered trashy in Ghana - a habit reserved for expats and their friends.

Do expect to be stopped at police checkpoints along Ghana's roads. Be sure to have your international driver's license if you're behind the wheel.

Do be aware that, in rare instances, visitors arriving in Ghana with electronic equipment, particularly video cameras and laptop computers, have had to pay a deposit of 17.5 percent of the item's value. To get the deposit refunded, visitors must apply to the Customs and Excise Office in central Accra 48 hours before departure.

Don't photograph sensitive areas (i.e., bridges, airports, any government structure, etc.) and always ask before taking someone's photograph.

Do shake hands when greeting and leaving people.

Don't deal in gold, farm commodities and diamonds with private citizens unless you get prior governmental permission.

A running joke in Ghana says GMT is not the acronym for Greenwich Mean Time, but for Ghana Maybe Time. It can happen people are not exactly at the right time of the appointment.

Don't drive through Accra at night if your car has foreign license plates - it's not allowed.

Do declare all currency and valuables upon arrival and be thorough when filling out currency-declaration forms. Authorities take currency "crimes" very seriously. Make sure you have your papers properly marked when you change money at authorized sites. If things don't tally up when you leave, it will be assumed you've changed money on the black market or that you sold something valuable without paying taxes, and you may find yourself in serious trouble - currency receipts are always inspected on departure. Don't attempt to take cedis into the country: Doing so is illegal. (There's no point, really - the cedis is traded at very reasonable rates in official "Forex" bureaus in large cities and at border crossings.) Any transaction involving diamonds or gold, if not conducted through government agencies, is illegal.